Don't be fooled-A no-observed-effect concentration is no substitute for a poor concentration-response experiment
نویسندگان
چکیده
منابع مشابه
A Bayesian approach for determining the no effect concentration and hazardous concentration in ecotoxicology.
This paper describes a Bayesian modeling approach to the estimation of the no effect concentration (NEC) and the hazardous concentration (HC(x)) as an alternative to conventional methods based on NOECs - the no observed effect concentration. The advantage of the proposed method is that it combines a plausible model for dose-response data with prior information or belief about the model's parame...
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The no observed effect concentration (NOEC) is currently a major summary statistic in ecotoxicity testing. Its use is heavily criticized, partly because it is a poor estimator of ‘‘safe’’ chemical concentrations. In this short communication, we review the limited information available on the percentage effect that corresponds with the NOEC, a value designated the ECNOEC, and calculate ECNOEC va...
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Clarity about the nitric oxide (NO) concentrations existing physiologically is essential for developing a quantitative understanding of NO signalling, for performing experiments with NO that emulate reality, and for knowing whether or not NO concentrations become abnormal in disease states. A decade ago, a value of about 1 microM seemed reasonable based on early electrode measurements and a pro...
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The author wishes to thank the Institute of Turkish Studies, Georgetown University; and the Political Economy Research Institute, University of Massachusetts Amherst for funding this research. In addition, she is grateful to Mohan Rao and James Boyce for their insightful comments and questions. The author is particularly indebted to the Turkish Ministry of Agriculture and to Levent Yener, direc...
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CONTEXT Toxic shock syndrome has been shown previously to be associated with hyperamylasaemia. However, serum amylase levels do not usually exceed three times upper limit of normal in these cases. CASE REPORT We report a case of a young girl of 17 years who presented with upper abdominal pain, severe shock and raised serum amylase level of 3,898 U/L, giving an impression of severe acute pancr...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Chemistry
سال: 2016
ISSN: 0730-7268
DOI: 10.1002/etc.3459